Stefan runs away and attempts to start a new life on his own in a town called Fells Church, a town located in the American state of Virginia (it is later said that a powerful force of some sorts drew Stefan to Fells Church, although he couldn't understand why he was drawn to the town in the first place). After Katherine's 'fake death', the heartbreak he endured after thinking he lost her and the continuous tumultuous relationship in which he had shared with his elder brother, Damon, Stefan makes an attempt to run far away and start a new life somewhere else, away from his dark and haunting past. Katherine was the one who transformed both of the Salvatore brothers into vampires. Katherine was Stefan's as well as his brother Damon's creator.

Stefan is the second and youngest son of Giuseppe, Conte di Salvatore and his un-named mother (who died a few years after he was born), the younger brother of Damon Salvatore, the past love and object of obsession of Katherine von Swartzschild, the soulmate of Elena Gilbert, close friend of Bonnie McCullough and Meredith Sulez, best friend of Matt Honeycutt, ally of Zander, former fling of Caroline Forbes, a rival of Tyler Smallwood and enemies with Misao, Shinichi, and Klaus. He is vampire born during the time of the Renaissance, making him over five hundred years old.He was one of the Salvatore brothers that fell in love with Katherine von Swartzschild during his human life (which was the time of the Italian Renaissance) and before he was transformed into a vampire. Stefan Salvatore ( Italian: Stefano Salvatore) is a protagonist, the main male character (opposite of Elena, the female protagonist) and the deuteragonist overall of The Vampire Diaries novel series.

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